Epstein-Barr virus and telomerase: from cell immortalization to therapy
Riccardo Dolcetti, Silvia Giunco, Jessica Dal Col, Andrea Celeghin, Katy Mastorci, Anita De Rossi
Infectious Agents and Cancer | BIOMED CENTRAL LTD | Published : 2014
Overcoming cellular senescence is strictly required for virus-driven tumors, including those associated with Epstein-Barr virus (EBV). This critical step is successfully accomplished by EBV through TERT expression and telomerase activation in infected cells. We herein review the complex interplay between EBV and TERT/telomerase in EBV-driven tumorigenesis. Evidence accumulated so far clearly indicates that elucidation of this issue may offer promising opportunities for the design of innovative treatment modalities for EBV-associated malignancies. Indeed, several therapeutic strategies for telomerase inhibition have been developed and are being investigated in clinical trials. In this respect..View full abstract
Awarded by Associazione Italiana per la Ricerca sul Cancro
The study was supported in part by grants from the Associazione Italiana per la Ricerca sul Cancro (Contract 14287 to R.D. and Contract 14258 to A.D.R.).