Interplay among viral antigens, cellular pathways and tumor microenvironment in the pathogenesis of EBV-driven lymphomas
Riccardo Dolcetti, Jessica Dal Col, Debora Martorelli, Antonino Carbone, Eva Klein
Seminars in Cancer Biology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2013
Epstein-Barr virus (EBV) is a ubiquitous human γ-herpes virus that has established an elegant strategy to persist as a life-long asymptomatic infection in memory B lymphocytes. EBV has potent transforming properties for B lymphocytes and it is pathogenically associated with a variety of lymphomas of B or NK/T cell origin. The viral latency programs expressed can hijack or deregulate cellular pathways critical for cell proliferation and survival, while impairing anti-viral immune responses. Similar effects may also be induced by EBV-encoded micro-RNAs, which may have a pathogenic role particularly in lymphomas showing a restricted expression of viral proteins. Of note, recent data have challe..View full abstract
Awarded by Associazione Italiana per la Ricerca sul Cancro
The study was supported by a grant from the Associazione Italiana per la Ricerca sul Cancro (contract 10301 to R.D.) and from the Swedish Cancer Society (Cancerfonden).