Journal article

hTERT inhibits the Epstein-Barr virus lytic cycle and promotes the proliferation of primary B lymphocytes: Implications for EBV-driven lymphomagenesis

Liliana Terrin, Riccardo Dolcetti, Irene Corradini, Stefano Indraccolo, Jessica Dal Col, Roberta Bertorelle, Laura Bonaldi, Giovanni Esposito, Anita De Rossi

International Journal of Cancer | WILEY | Published : 2007

Abstract

Transformation of primary B lymphocytes by Epstein-Barr Virus (EBV) requires the establishment of a latent infection, the expression of several latent viral proteins and a sustained telomerase activity. We investigated the interplay between the activation of human telomerase reverse transcriptase (hTERT), the catalytic rate-limiting component of the telomerase complex, and the expression of latent/lytic EBV genes during the establishment of a stably latent EBV infection of normal B lymphocytes. Cell cultures at early passages after EBV infection greatly differed in their timing of hTERT expression and telomerase activation. Induction of hTERT was dependent on the balance between latent and l..

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