Journal article
Proteins specifically hyperexpressed in a coeliac disease patient with aberrant T cells
V De Re, MP Simula, L Caggiari, N Orzes, M Spina, A Da ponte, L De Appollonia, R Dolcetti, V Canzonieri, R Cannizzaro
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | WILEY | Published : 2007
Abstract
An aberrant T cell population is the basis for diagnosis of refractory coeliac disease and determines the risk of enteropathy-associated T cell lymphoma. This disease is serious with a poor survival. Pathogenetic mechanisms sustaining aberrant T cell proliferation remain unknown. Recently, alemtuzumab has been proposed as a promising new approach to treat these patients. Only few single cases have been tested at present; nevertheless, in all the cases a clinical improvement was observed. However, whether intraepithelial lymphocytes have been targeted effectively by alemtuzumab is still debated. This study reports, using two-dimensional difference gel electrophoresis (2D DIGE), hyperexpressed..
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