Journal article

Bacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: A multicenter prospective trial

Andres JM Ferreri, Maurilio Ponzoni, Massimo Guidoboni, Antonio Giordano Resti, Letterio S Politi, Sergio Cortelazzo, Judit Demeter, Francesco Zallio, Angelo Palmas, Giuliana Muti, Giuseppina P Dognini, Elisa Pasini, Antonia Anna Lettini, Federico Sacchetti, Carlo De Conciliis, Claudio Doglioni, Riccardo Dolcetti

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | OXFORD UNIV PRESS INC | Published : 2006

Abstract

BACKGROUND: An association between ocular adnexal MALT lymphoma (OAL) and Chlamydia psittaci (Cp) infection has been proposed, and recent reports suggest that doxycycline treatment causes tumor regression in patients with Cp-related OAL. The effectiveness of doxycycline treatment in Cp-negative OAL has not been tested. METHODS: In a prospective trial, 27 OAL patients (15 newly diagnosed and 12 having experienced relapse) were given a 3-week course of doxycycline therapy. Objective lymphoma response was assessed by computerized tomography scans or magnetic resonance imaging at 1, 3, and 6 months after the conclusion of therapy and every 6 months during follow-up. Cp infection in patients was ..

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