Journal article

Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas

AJM Ferreri, M Guidoboni, M Ponzoni, C De Conciliis, S Dell'Oro, K Fleischhauer, L Caggiari, AA Lettini, E Dal Cin, R Ieri, M Freschi, E Villa, M Boiocchi, R Dolcetti

JOURNAL OF THE NATIONAL CANCER INSTITUTE | OXFORD UNIV PRESS INC | Published : 2004

Abstract

BACKGROUND: Ocular adnexal lymphomas may be antigen-driven disorders; however, the source of the putative antigen or antigens is still unknown. Hence, we assessed whether Chlamydiae infection is associated with the development of ocular adnexal lymphomas. METHODS: The presence of Chlamydia psittaci, trachomatis, and pneumoniae DNA was investigated by polymerase chain reaction in 40 ocular adnexal lymphoma samples, 20 nonneoplastic orbital biopsies, 26 reactive lymphadenopathy samples, and peripheral blood mononuclear cells (PBMCs) from 21 lymphoma patients and 38 healthy individuals. Seven patients with chlamydia-positive PBMCs were treated with the antibiotic doxycycline, and objective resp..

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