Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders
Luigi Buonaguro, Annacarmen Petrizzo, Marialina Tornesello, Maria Napolitano, Debora Martorelli, Giuseppe Castello, Gerardo Beneduce, Amalia De Renzo, Oreste Perrella, Luca Romagnoli, Vitor Sousa, Valli De Re, Riccardo Dolcetti, Franco M Buonaguro
Journal of Translational Medicine | BMC | Published : 2010
Hepatitis C virus (HCV) is one of the major risk factors for chronic hepatitis, which may progress to cirrhosis and hepatocellular carcinoma, as well as for type II mixed cryoglobulinemia (MC), which may further evolve into an overt B-cell non-Hodgkin's lymphoma (NHL). It has been previously shown that B-cell receptor (BCR) repertoire, expressed by clonal B-cells involved in type II MC as well as in HCV-associated NHL, is constrained to a limited number of variable heavy (VH)- and light (VL)-chain genes. Among these, the VK3-20 light chain idiotype has been selected as a possible target for passive as well as active immunization strategy. In the present study, we describe the results of a mu..View full abstract
Awarded by European Community
Awarded by Italian Ministry of Health program "Alleanza Contro il Cancro
The study was supported in part by grants from the European Community (FP6 VITAL, Contract no.: 037874), and the Italian Ministry of Health program "Alleanza Contro il Cancro (ACC-4)".