Journal article

Exploiting the Interplay between Innate and Adaptive Immunity to Improve Immunotherapeutic Strategies for Epstein-Barr-Virus-Driven Disorders

Debora Martorelli, Elena Muraro, Anna Merlo, Riccardo Turrini, Damiana Antonia Fae, Antonio Rosato, Riccardo Dolcetti

Clinical and Developmental Immunology | HINDAWI LTD | Published : 2012


The recent demonstration that immunotherapeutic approaches may be clinically effective for cancer patients has renewed the interest for this strategy of intervention. In particular, clinical trials using adoptive T-cell therapies disclosed encouraging results, particularly in the context of Epstein-Barr-virus- (EBV-) related tumors. Nevertheless, the rate of complete clinical responses is still limited, thus stimulating the development of more effective therapeutic protocols. Considering the relevance of innate immunity in controlling both infections and cancers, innovative immunotherapeutic approaches should take into account also this compartment to improve clinical efficacy. Evidence accu..

View full abstract


Awarded by European Community

Awarded by Italian Ministry of Health

Awarded by Associazione Italiana per la Ricerca sul Cancro

Funding Acknowledgements

The study was supported in part by Grants from the European Community (FP6 VITAL, Contract no. 037874), the Italian Ministry of Health program "Alleanza Contro il Cancro" (ACC-4), the Associazione Italiana per la Ricerca sul Cancro (Contract 10301 to R. Dolcetti), and the Fondazione Federica per la Vita.