Journal article

Fighting viral infections and virus-Driven Tumors with Cytotoxic CD4( ) T Cells

Elena Muraro, Anna Merlo, Debora Martorelli, Michela Cangemi, Silvia Dalla Santa, Riccardo Dolcetti, Antonio Rosato

Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2017


CD4+ T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion, and specific functions. Nonetheless, a growing body of evidence indicates that CD4+ T cells can also exert a direct effector activity, which depends on intrinsic cytotoxic properties acquired and carried out along with the evolution of several pathogenic infections. The relevant role of CD4+ T cell lytic features in the control of such infectious conditions also leads to their exploitation as a new immunotherapeutic approach. This review aims at..

View full abstract


Awarded by Italian Association for Cancer Research (AIRC)

Funding Acknowledgements

This work was partly supported by grants from the Italian Association for Cancer Research (AIRC, IG-17035 and Special Program Molecular Clinical Oncology 5 per mille ID 10016) and Progetto di Ricerca di Ateneo 2015, University of Padova, to AR.