Journal article

Fighting viral infections and virus-Driven Tumors with Cytotoxic CD4( ) T Cells

Elena Muraro, Anna Merlo, Debora Martorelli, Michela Cangemi, Silvia Dalla Santa, Riccardo Dolcetti, Antonio Rosato

Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2017

Abstract

CD4+ T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion, and specific functions. Nonetheless, a growing body of evidence indicates that CD4+ T cells can also exert a direct effector activity, which depends on intrinsic cytotoxic properties acquired and carried out along with the evolution of several pathogenic infections. The relevant role of CD4+ T cell lytic features in the control of such infectious conditions also leads to their exploitation as a new immunotherapeutic approach. This review aims at..

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Grants

Awarded by Italian Association for Cancer Research (AIRC)


Funding Acknowledgements

This work was partly supported by grants from the Italian Association for Cancer Research (AIRC, IG-17035 and Special Program Molecular Clinical Oncology 5 per mille ID 10016) and Progetto di Ricerca di Ateneo 2015, University of Padova, to AR.