Phospholipid scramblase 1 as a critical node at the crossroad between autophagy and apoptosis in mantle cell lymphoma
Katy Mastorci, Barbara Montico, Damiana A Fae, Luca Sigalotti, Maurilio Ponzoni, Giorgio Inghirami, Riccardo Dolcetti, Jessica Dal Col
Oncotarget | IMPACT JOURNALS LLC | Published : 2016
Mantle cell lymphoma (MCL) is an aggressive haematological malignancy in which the response to therapy can be limited by aberrantly activated molecular and cellular pathways, among which autophagy was recently listed. Our study shows that the 9-cis-retinoic acid (RA)/Interferon(IFN)-α combination induces protective autophagy in MCL cell lines and primary cultures reducing the extent of drug-induced apoptosis. The treatment significantly up-regulates phospholipid scramblase 1 (PLSCR1), a protein which bi-directionally flips lipids across membranes. In particular, RA/IFN-α combination concomitantly increases PLSCR1 transcription and controls PLSCR1 protein levels via lysosomal degradation. Her..View full abstract
Awarded by Italian Association for Cancer Research
This study was supported by: Italian Association for Cancer Research (My First Grant MFAG 11729 to JDC, and contract 14257 to RD), "CRO Intramural Bench to Bedside" Grant 2012 (to RD). KM was supported by an Italian Foundation for Cancer Research fellowship.