Journal article

Prognostic significance of LINE-1 hypomethylation in oropharyngeal squamous cell carcinoma

Carlo Furlan, Jerry Polesel, Luigi Barzan, Giovanni Franchin, Sandro Sulfaro, Salvatore Romeo, Francesca Colizzi, Aurora Rizzo, Vittorio Baggio, Vittorio Giacomarra, Angelo Paolo Dei Tos, Paolo Boscolo-Rizzo, Emanuela Vaccher, Riccardo Dolcetti, Luca Sigalotti, Elisabetta Fratta

Clinical Epigenetics | BIOMED CENTRAL LTD | Published : 2017

Abstract

BACKGROUND: Inclusion of new biomarkers to improve a personalized treatment approach for oropharyngeal squamous cell carcinoma (OPSCC) is urgently needed. Hypomethylation of the Long interspersed nucleotide element-1 (LINE-1) repetitive elements, a widely accepted surrogate of overall genomic DNA methylation content, was found to be associated with a poor prognosis in several cancers. At present, no studies have investigated the influence of LINE-1 methylation levels on OPSCC relapse. The main goal of this study was the evaluation of the prognostic value of LINE-1 methylation status in predicting early tumor relapse in locally advanced OPSCC. METHODS: We retrospectively reviewed a cohort of ..

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Grants

Awarded by Associazione Italiana per la Ricerca sul Cancro


Funding Acknowledgements

This study was supported by grants from the Associazione Italiana per la Ricerca sul Cancro (contract 14287 to RD) and from the Centro di Riferimento Oncologico, IRCCS-National Cancer Institute (Intramural Grant to LS and 5 x 1000 Institutional Grant to EF).