Journal article
HCV-related liver and lymphoproliferative diseases: Association with polymorphisms of IL28B and TLR2
V de Re, M de Zorzi, L Caggiari, G Lauletta, ML Tornesello, E Fognani, M Miorin, V Racanelli, L Quartuccio, L Gragnani, S Russi, F Pavone, M Ghersetti, EG Costa, P Casarin, R Bomben, C Mazzaro, G Basaglia, M Berretta, E Vaccher Show all
Oncotarget | IMPACT JOURNALS LLC | Published : 2016
Abstract
To explore the relationship between innate immunity and hepatitis C Virus (HCV) in determining the risk of cirrhosis (CIR), hepatocellular carcinoma (HCC), mixed cryoglobulinemia syndrome (MCS) and non-Hodgkin lymphoma (NHL), we investigated the impact of the toll-like receptor-2 (TLR2) and interleukin-28B (IL28B) genetic variants. TLR2 -174 del variant was associated with TLR2 expression and with specific downstream molecules that drive the expression of different interleukins; rs12979860 Il28B was important in response to interferon-treatment and in spontaneous clearance of HCV. The risk for liver and lymphoproliferative diseases in HCV progression was clarified by stratifying 862 HCV-posi..
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Awarded by Associazione Italiana per la Ricerca sul Cancro
Funding Acknowledgements
This work was supported by The Associazione Italiana Ricerca Cancro (AIRC), Investigator Grant IG-14973.