Journal article

Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria

Tao Huang, James A Holden, Eric C Reynolds, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

ACS APPLIED MATERIALS & INTERFACES | AMER CHEMICAL SOC | Published : 2020

Abstract

Antibiotic-resistant bacteria are a severe threat to human health. The World Health Organization's Global Antimicrobial Surveillance System has revealed widespread occurrence of antibiotic resistance among half a million patients across 22 countries, with Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae being the most common resistant species. Antimicrobial nanoparticles are emerging as a promising alternative to antibiotics in the fight against antimicrobial resistance. In this work, selenium nanoparticles coated with the antimicrobial polypeptide, ε-poly-l-lysine, (Se NP-ε-PL) were synthesized and their antibacterial activity and cytotoxicity were investigated. Se NP-ε-PL..

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Grants

Awarded by NHMRC


Awarded by ARC


Awarded by Cancer Council Victoria


Funding Acknowledgements

The National Health and Medical Research Council (NHMRC) of Australia and Australian Research Council (ARC) are thanked for financial support over many years for the nanomaterials, peptide chemistry, and chemical biology studies reported in the authors' laboratories. N.M.O.-S. is the recipient of NHMRC funding (APP1142472, APP1158841, and APP1185426), ARC funding (DP160101312 and LE200100163), Cancer Council Victoria funding (APP1163284), and Australian Dental Research Funding in antimicrobial materials, and the research is supported by the Centre for Oral Health Research at the Melbourne Dental School. J.A.H. is the recipient of NHMRC funding (APP1185426) and Australian Dental Research Funding in antimicrobial materials, and the research is supported by the Centre for Oral Health Research at the Melbourne Dental School. A. J. O. is the recipient of ARC funding (IC180100024) and NHMRC funding (APP1183278). D.E.H. is the recipient of ARC funding (FT190100280). A.J.O., D.E.H., and N.M.O.-S. are recipients of funding from The Acceleration Fund of the Department of Health and Human Services, Victoria, Australia. T.H. gratefully acknowledges the support of the University of Melbourne and an Australian Government Research Training Program Scholarship (Melbourne International Research Scholarship). The authors thank Babak Nasr for help with HIM imaging, the Bio21 Advanced Microscopy Facility (the University of Melbourne), and the Materials Characterization and Fabrication Platform (the University of Melbourne) for access to infrastructure and equipment.