Journal article

Neurocognitive Dysfunction and Smaller Brain Volumes in Adolescents and Adults With a Fontan Circulation

Charlotte E Verrall, Joseph YM Yang, Jian Chen, Adrian Schembri, Yves d'Udekem, Diana Zannino, Nadine A Kasparian, Karin du Plessis, Stuart M Grieve, Thomas Welton, Belinda Barton, Thomas L Gentles, David S Celermajer, Chantal Attard, Kathryn Rice, Julian Ayer, Simone Mandelstam, David S Winlaw, Mark T Mackay, Rachael Cordina

Circulation | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021

Abstract

BACKGROUND: Neurocognitive outcomes beyond childhood in people with a Fontan circulation are not well defined. This study aimed to investigate neurocognitive functioning in adolescents and adults with a Fontan circulation and associations with structural brain injury, brain volumetry, and postnatal clinical factors. METHODS: In a binational study, participants with a Fontan circulation without a preexisting major neurological disability were prospectively recruited from the Australia and New Zealand Fontan Registry. Neurocognitive function was assessed by using Cogstate software in 107 participants with a Fontan circulation and compared with control groups with transposition of the great art..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

This project was supported by a grant from the National Health and Medical Research Council (Project Grant 1047923) and a Heart Kids Grant in Aid.