Journal article
Neurocognitive Dysfunction and Smaller Brain Volumes in Adolescents and Adults with a Fontan Circulation
CE Verrall, JYM Yang, J Chen, A Schembri, Y D'Udekem, D Zannino, NA Kasparian, K Du Plessis, SM Grieve, T Welton, B Barton, TL Gentles, DS Celermajer, C Attard, K Rice, J Ayer, S Mandelstam, DS Winlaw, MT Mackay, R Cordina
Circulation | Published : 2021
Abstract
Background: Neurocognitive outcomes beyond childhood in people with a Fontan circulation are not well defined. This study aimed to investigate neurocognitive functioning in adolescents and adults with a Fontan circulation and associations with structural brain injury, brain volumetry, and postnatal clinical factors. Methods: In a binational study, participants with a Fontan circulation without a preexisting major neurological disability were prospectively recruited from the Australia and New Zealand Fontan Registry. Neurocognitive function was assessed by using Cogstate software in 107 participants with a Fontan circulation and compared with control groups with transposition of the great art..
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Awarded by National Institutes of Health
Funding Acknowledgements
This project was supported by a grant from the National Health and Medical Research Council (Project Grant 1047923) and a Heart Kids Grant in Aid.