Journal article
Neurocognitive Dysfunction and Smaller Brain Volumes in Adolescents and Adults With a Fontan Circulation
Charlotte E Verrall, Joseph YM Yang, Jian Chen, Adrian Schembri, Yves d'Udekem, Diana Zannino, Nadine A Kasparian, Karin du Plessis, Stuart M Grieve, Thomas Welton, Belinda Barton, Thomas L Gentles, David S Celermajer, Chantal Attard, Kathryn Rice, Julian Ayer, Simone Mandelstam, David S Winlaw, Mark T Mackay, Rachael Cordina
Circulation | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021
Abstract
BACKGROUND: Neurocognitive outcomes beyond childhood in people with a Fontan circulation are not well defined. This study aimed to investigate neurocognitive functioning in adolescents and adults with a Fontan circulation and associations with structural brain injury, brain volumetry, and postnatal clinical factors. METHODS: In a binational study, participants with a Fontan circulation without a preexisting major neurological disability were prospectively recruited from the Australia and New Zealand Fontan Registry. Neurocognitive function was assessed by using Cogstate software in 107 participants with a Fontan circulation and compared with control groups with transposition of the great art..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This project was supported by a grant from the National Health and Medical Research Council (Project Grant 1047923) and a Heart Kids Grant in Aid.