Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: Improvement in body composition and fasting insulin

Abstract

Context: Metformin therapy for adults and children with type 2 diabetes is well established. However, its role in the treatment of insulin resistance and obesity in children and adolescents is less clearly defined. Objective: We assessed the effect of metformin on body composition and insulin sensitivity in pediatric subjects with exogenous obesity. Design and Setting: Patients referred to a pediatric endocrine clinic were enrolled in a randomized, double-blind, crossover trial. Patients: Twenty-eight patients (13 males) aged 9-18 yr participated in the study. Intervention: Patients received metformin (1 g twice daily) and placebo for 6 months, each with a 2-wk washout period. Main Outcome M..