Journal article

Angiotensin converting enzyme genotypes and mortality from COVID-19: An ecological study

Ar K Aung, Tess Aitken, Bing M Teh, Christiaan Yu, Richard Ofori-Asenso, Ken L Chin, Danny Liew

Journal of Infection | W B SAUNDERS CO LTD | Published : 2020

Abstract

BACKGROUND: Angiotensin converting enzyme (ACE) genotypes are known to be associated with development of acute respiratory distress syndrome (ARDS) and resultant mortality. In the present study, we examined the association between distribution frequency of ACE genotypes and COVID-19 mortality. METHODS: We undertook an ecological study to examine the association between ACE genotypes and COVID-19 mortality across 25 countries to represent different geographical regions of the world. The population frequencies of ACE genotypes were drawn from previously published reports and data on COVID-19-related mortality were extracted from 'Worldometer'. Multivariable analyses were also undertaken adjust..

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