Could HPV Testing on Self-collected Samples Be Routinely Used in an Organized Cervical Screening Program? A Modeled Analysis
Megan A Smith, Michaela T Hall, Marion Saville, Julia ML Brotherton, Kate T Simms, Jie-Bin Lew, Deborah Bateson, S Rachel Skinner, Margaret Kelaher, Karen Canfell
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | AMER ASSOC CANCER RESEARCH | Published : 2021
BACKGROUND: Cervical screening on self-collected samples has mainly been considered for targeted use in underscreened women. Updated evidence supports equivalent sensitivity of PCR-based human papillomavirus (HPV) testing on self-collected and clinician-collected samples. METHODS: Using a well-established model, we compared the lifetime impact on cancer diagnoses and deaths resulting from cervical screening using self-collected samples only, with and without the existing restriction in Australia to women aged 30+ years and ≥2 years overdue, compared with the mainstream program of 5-yearly HPV screening on clinician-collected samples starting at 25 years of age. We conservatively assumed sens..View full abstract
Awarded by National Health and Medical Research Council
Awarded by Cancer Institute NSW
This study was funded by Cancer Council NSW, a nongovernment charity, and grants from the National Health and Medical Research Council (APP1159491 to M.A. Smith and APP1135172 to M.A. Smith and K.T. Simms) and Cancer Institute NSW (ECF181561 to M.A. Smith).