Journal article

Heterogeneity in microstructural deterioration following spinal cord injury

Ali Ghasem-Zadeh, Mary P Galea, Andrew Nunn, Maya Panisset, Xiao-Fang Wang, Sandra Iuliano, Steven K Boyd, Mark R Forwood, Ego Seeman

BONE | ELSEVIER SCIENCE INC | Published : 2021

Abstract

BACKGROUND: Modelling and remodelling adapt bone morphology to accommodate strains commonly encountered during loading. If strains exceed a threshold threatening fracture, modelling-based bone formation increases bone volume reducing these strains. If unloading reduces strains below a threshold that inhibits resorption, increased remodelling-based bone resorption reduces bone volume restoring strains, but at the price of compromised bone volume and microstructure. As weight-bearing regions are adapted to greater strains, we hypothesized that microstructural deterioration will be more severe than at regions commonly adapted to low strains following spinal cord injury. METHODS: We quantified d..

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