The Carbonylation of Organic Compounds by Visible Light Photoredox Catalysis

Abstract

Palladium-catalysed alkoxy- and aminocarbonylation of aryl (pseudo)halides provides efficient access to aromatic esters and amides. The broad application of this approach has been restricted by functional group tolerance, high reaction temperatures and moderate catalyst efficiency. Free-radical carbonylation is a complementary approach not confined by the same inherent limitations of palladium-catalysed carbonylative cross-coupling methodology. The development of free-radical carbonylation has been hindered by the ability to selectively generate the carbon-centred radical species and the high pressures of carbon monoxide required to drive the carbonylation step. This thesis describes the de..