Ribosomal protein depletion in the Drosophila haematopoietic compartment alters cell fate determination

Abstract

Ribosomes are essential components of the translational machinery, required for cells to effectively double their protein content in order to undergo cell division. Despite the obvious need for ribosomes, due to the high energetic cost, ribosome biogenesis is tightly regulated by numerous pathways in response to cellular and extracellular signalling cues. Predictably, dysregulation of ribosome levels strongly correlates with disease. Increased ribosome biogenesis is observed in many cancers and decreased ribosome biogenesis underlies a class of developmental disorders collectively termed ribosomopathies. Somewhat surprisingly, given the ubiquitous need for ribosomes, loss of ribosomal protei..