Diabetic Kidney Disease with a focus on Renal Hyperfiltration

Abstract

Currently, it is not known if the process of renal hyperfiltration is adaptive as a compensatory effect akin to pregnancy or is maladaptive and can result in non-reversible renal damage and the development of diabetic kidney disease. The overall aim of my study was to investigate renal hyperfiltration in diabetes, by comparing this to renal hyperfiltration in pregnancy, assessing renal biomarkers and utilizing functional magnetic resonance imaging. Estimated glomerular filtration rate based on The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula was used as the main surrogate measurement of renal function in this thesis. Where possible, measured glomerular filtration rat..