Quantitative lipidomic analysis of Ascaris suum
Tao Wang, Shuai Nie, Guangxu Ma, Johnny Vlaminck, Peter Geldhof, Nicholas A Williamson, Gavin E Reid, Robin B Gasser
PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2020
Ascaris is a soil-transmitted nematode that causes ascariasis, a neglected tropical disease affecting predominantly children and adolescents in the tropics and subtropics. Approximately 0.8 billion people are affected worldwide, equating to 0.86 million disability-adjusted life-years (DALYs). Exploring the molecular biology of Ascaris is important to gain a better understanding of the host-parasite interactions and disease processes, and supports the development of novel interventions. Although advances have been made in the genomics, transcriptomics and proteomics of Ascaris, its lipidome has received very limited attention. Lipidomics is an important sub-discipline of systems biology, focu..View full abstract
Research funding from the Australian Research Council (ARC) and National Health and Medical Research Council (NHMRC) is gratefully acknowledged (RBG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.