Inhibition of interleukin-1 beta signalling promotes atherosclerotic lesion remodelling in mice with inflammatory arthritis
Dragana Dragoljevic, Man Kit Sam Lee, Cynthia Louis, Waled Shihata, Michael J Kraakman, Jacinta Hansen, Seth L Masters, Beatriz Y Hanaoka, Prabhakara R Nagareddy, Graeme Lancaster, Ian P Wicks, Andrew J Murphy
CLINICAL & TRANSLATIONAL IMMUNOLOGY | WILEY | Published : 2020
Objectives: Rheumatoid arthritis (RA), an inflammatory joint disorder, independently increases the risk of cardiovascular disease (CVD). IL-1β contributes to both RA and CVD. We hypothesised that inhibiting IL-1 signalling with the IL-1R antagonist, anakinra, would dampen inflammation and promote resolution of atherosclerosis in arthritic mice. Methods: Low-density lipoprotein receptor (Ldlr)-deficient mice were fed a Western-type diet for 14 weeks to develop atherosclerotic plaques. Mice were then switched to a chow diet, promoting lesion regression, and randomised to a control group or into groups where arthritis was induced by passive transfer of K/BxN arthritogenic serum. The arthritic m..View full abstract
Awarded by NHMRC Australia Clinical Practitioner Fellowship
Awarded by NHMRC Program Grant
Awarded by NIH
This study was supported by a CSL Centenary Award to AJM. IPW was supported by the Reid Charitable Trusts, an NHMRC Australia Clinical Practitioner Fellowship (1154235) and an NHMRC Program Grant (1113577). PRN is supported by grants from the NIH (R01HL137799 & R00HL122505).