Journal article

DKC1 Overexpression Induces a More Aggressive Cellular Behavior and Increases Intrinsic Ribosomal Activity in Immortalized Mammary Gland Cells

Ania Naila Guerrieri, Federico Zacchini, Carmine Onofrillo, Sara Di Viggiano, Marianna Penzo, Alessio Ansuini, Ilaria Gandin, Yuko Nobe, Masato Taoka, Toshiaki Isobe, Davide Trere, Lorenzo Montanaro

Cancers | MDPI | Published : 2020

Abstract

Dyskerin is a nucleolar protein involved in the small nucleolar RNA (snoRNA)-guided pseudouridylation of specific uridines on ribosomal RNA (rRNA), and in the stabilization of the telomerase RNA component (hTR). Loss of function mutations in DKC1 causes X-linked dyskeratosis congenita, which is characterized by a failure of proliferating tissues and increased susceptibility to cancer. However, several tumors show dyskerin overexpression. We observed that patients with primary breast cancers with high dyskerin levels are more frequently characterized by shorter survival rates and positive lymph node status than those with tumors with a lower dyskerin expression. To functionally characterize t..

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Grants

Awarded by Fondazione AIRC per la Ricerca sul Cancro (AIRC)


Funding Acknowledgements

This work was supported by Fondazione AIRC per la Ricerca sul Cancro (AIRC), IG 16962 and IG 21562 to L.M., and by funds from the Pallotti Legacy for Cancer Research to L.M., D.T., and M.P.