Book Chapter

Network patterning, morphogenesis and growth in lymphatic vascular development.

Lin Grimm, Benjamin M Hogan

Current Topics in Developmental Biology | Current Topics in Developmental Biology | Published : 2021


The lymphatic vasculature is a vital component of the vertebrate vascular system that mediates tissue fluid homeostasis, lipid uptake and immune surveillance. The development of the lymphatic vasculature starts in the early vertebrate embryo, when a subset of blood vascular endothelial cells of the cardinal veins acquires lymphatic endothelial cell fate. These cells sprout from the veins, migrate, proliferate and organize to give rise to a highly structured and unique vascular network. Cellular cross-talk, cell-cell communication and the interpretation of signals from surrounding tissues are all essential for coordinating these processes. In this chapter, we highlight new findings and review..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council