Major SCP/TAPS protein expansion in Lucilia cuprina is associated with novel tandem array organisation and domain architecture
Yair DJ Prawer, Andreas J Stroehlein, Neil D Young, Shilpa Kapoor, Ross S Hall, Razi Ghazali, Phillip Batterham, Robin B Gasser, Trent Perry, Clare A Anstead
Parasites & Vectors | BMC | Published : 2020
BACKGROUND: Larvae of the Australian sheep blowfly, Lucilia cuprina, parasitise sheep by feeding on skin excretions, dermal tissue and blood, causing severe damage known as flystrike or myiasis. Recent advances in -omic technologies and bioinformatic data analyses have led to a greater understanding of blowfly biology and should allow the identification of protein families involved in host-parasite interactions and disease. Current literature suggests that proteins of the SCP (Sperm-Coating Protein)/TAPS (Tpx-1/Ag5/PR-1/Sc7) (SCP/TAPS) superfamily play key roles in immune modulation, cross-talk between parasite and host as well as developmental and reproductive processes in parasites. METHOD..View full abstract
Funding from Australian Wool Innovation (AWI; to C.A.A. and T.P., and P.B. and R.B.G.) is gratefully acknowledged. AWI is grateful for its funding, which is primarily provided by Australian woolgrowers through a wool levy, and by the Australian Government which provides a matching contribution for eligible R&D activities. Funding also provided from the National Health and Medical Research Council (NHMRC) of Australia (to R.B.G. and N.D.Y.), the Australian Research Council (ARC) of Australia (to R.B.G.), and Melbourne Water Corporation (to R.B.G.). N.D.Y. holds an NHMRC Career Development Fellowship.