Journal article

Prior testosterone replacement therapy may impact spermatogenic response to combined gonadotropin therapy in severe congenital hypogonadotropic hypogonadism

Ravikumar Shah, Virendra Patil, Vijaya Sarathi, Anurag R Lila, Margaret Zacharin, Brijesh Krishnappa, Manjeetkaur Sehemby, Sanjeet Kumar Jaiswal, Pratap L Jadhav, Swati Ramteke-Jadhav, Nalini Shah, Tushar Bandgar

PITUITARY | SPRINGER | Published : 2020

Abstract

OBJECTIVE: To study the effect of prior testosterone replacement therapy (TRT) on the spermatogenic response to combined gonadotropin therapy (CGT) in severe and partial phenotype congenital hypogonadotropic hypogonadism (CHH) patients. DESIGN: Retrospective cohort study. SETTING: Tertiary care center. PATIENTS: Patients of CHH without (n = 17) and with prior TRT (n = 18) were subdivided into severe and partial groups, based on mean testicular volume ≤ 3 cc and > 3 cc respectively. INTERVENTION: Participants were treated with hMG at a dose of 75-150 U 3/week and gradually escalating doses of hCG until maximum dose (2000 U 3/week or 5000 U 2/week) or serum total testosterone of ≥ 3.5 ng/ml wa..

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