Journal article

Adolescent alcohol, nuts, and fiber: combined effects on benign breast disease risk in young women

Catherine S Berkey, Rulla M Tamimi, Walter C Willett, Bernard Rosner, Martha Hickey, Adetunji T Toriola, A Lindsay Frazier, Graham A Colditz

npj Breast Cancer | NATURE RESEARCH | Published : 2020


AbstractAdolescent drinking is associated with higher risks of proliferative benign breast disease (BBD) and invasive breast cancer (BC). Furthermore, adolescent nut and fiber consumptions are associated with lower risks of benign lesions and premenopausal BC. We hypothesize that diet (nuts, fiber) may mitigate the elevated BBD risk associated with alcohol. A prospective cohort of 9031 females, 9–15 years at baseline, completed questionnaires in 1996–2001, 2003, 2005, 2007, 2010, 2013, and 2014. Participants completed food frequency questionnaires in 1996–2001. In 2005, participants (>=18 years) began reporting biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression estimated..

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Awarded by National Institutes of Health (Bethesda, MD)

Funding Acknowledgements

The authors appreciate the ongoing, since 1996, dedication of our female GUTS participants and their mothers in NHSII. This study was supported by a grant from the Breast Cancer Research Foundation (NYC, NY) and by DK046834 from the National Institutes of Health (Bethesda, MD). G.A.C. was supported, in part, by an American Cancer Society Clinical Research Professorship. NIH provided funding for early data collection when the cohort was founded in 1996.