Journal article

The Emerging Role of the Prokineticins and Homeobox Genes in the Vascularization of the Placenta: Physiological and Pathological Aspects

Nadia Alfaidy, Sophie Brouillet, Gayathri Rajaraman, Bill Kalionis, Pascale Hoffmann, Tiphaine Barjat, Mohamed Benharouga, Padma Murthi

Frontiers in Physiology | FRONTIERS MEDIA SA | Published : 2020


Vasculogenesis and angiogenesis are key processes of placental development, which occur throughout pregnancy. Placental vasculogenesis occurs during the first trimester of pregnancy culminating in the formation of hemangioblasts from intra-villous stem cells. Placental angiogenesis occurs subsequently, forming new blood vessels from existing ones. Angiogenesis also takes place at the fetomaternal interface, allowing essential spiral arteriole remodeling to establish the fetomaternal circulation. Vasculogenesis and angiogenesis in animal models and in humans have been studied in a wide variety of in vitro, physiological and pathological conditions, with a focus on the pro- and anti-angiogenic..

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Awarded by Institut National de la Sante et de la Recherche Medicale

Funding Acknowledgements

We acknowledge the following sources of funding: Institut National de la Sante et de la Recherche Medicale (U1036), University of Grenoble Alpes, Commissariat a l'Energie Atomique (DSV/iRTSV/BCI), Region Auvergne-Rhone-Alpes "CLARA, Oncostarter," Ligue Nationale Contre le Cancer and Ligue Departementale (Savoie) Contre le Cancer, Inserm Transfert.