Journal article

A blinded, controlled trial of objective measurement in Parkinson's disease

Holly Woodrow, Malcolm K Horne, Chathurini V Fernando, Katya E Kotschet, Arup Bhattacharya, Arup Bhattacharya, Richard Blaze, Andrew Charmley, Belinda Cruse, Stephen Duma, Andrew Evans, Mina Ghaly, Blake Giarola, Amy J Halliday, Thomas Kimber, Anand Kumar, Alexander Lehn, Kate Lilley, Andrew Ma, Neil Mahant Show all

npj Parkinson's Disease | NATURE RESEARCH | Published : 2020


AbstractMedical conditions with effective therapies are usually managed with objective measurement and therapeutic targets. Parkinson’s disease has effective therapies, but continuous objective measurement has only recently become available. This blinded, controlled study examined whether management of Parkinson’s disease was improved when clinical assessment and therapeutic decisions were aided by objective measurement. The primary endpoint was improvement in the Movement Disorder Society-United Parkinson’s Disease Rating Scale’s (MDS-UPDRS) Total Score. In one arm, objective measurement assisted doctors to alter therapy over successive visits until objective measurement scores were in targ..

View full abstract


Funding Acknowledgements

This study was supported by grants from Parkinson's Victoria, Shake It Up Australia Foundation and The Michael J. Fox Foundation. G.K.C. provided the P.K.G. and loggers as a grant in aid.