Journal article

The gut microbiota in anxiety and depression - A systematic review

Carra A Simpson, Carmela Diaz-Arteche, Djamila Eliby, Orli S Schwartz, Julian G Simmons, Caitlin SM Cowan

CLINICAL PSYCHOLOGY REVIEW | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021

Abstract

Growing evidence indicates the community of microorganisms throughout the gastrointestinal tract, (i.e., gut microbiota), is associated with anxiety and depressive disorders. We present the first systematic review of the gut microbiota in anxiety disorders, along with an update in depression. Consideration of shared underlying features is essential due to the high rates of comorbidity. Systematic searches, following PRISMA guidelines, identified 26 studies (two case-control comparisons of the gut microbiota in generalised anxiety disorder, 18 in depression, one incorporating both anxiety/depression, and five including symptom-only measures). Alpha and beta diversity findings were inconsisten..

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Grants

Funding Acknowledgements

Carra Simpson and Djamila Eliby are supported by the Australian Government Research Training Program. Authors thank Ryan Carceller for his assistance with figure design. Figures created with BioRender. com.