Journal article

Evaluation of ResistancePlus MG FleXible, a 'near- patient' test for the detection of Mycoplasma genitalium and macrolide resistance mutations, using freshly collected clinical samples

Gerald L Murray, Michelle Doyle, Kaveesha Bodiyabadu, Lenka A Vodstrcil, Suzanne M Garland, Jennifer Danielewski, Dorothy A Machalek, Colette McGuinness, Erica L Plummer, Vesna De Petra, Deborah A Williamson, Catriona S Bradshaw

JOURNAL OF MEDICAL MICROBIOLOGY | MICROBIOLOGY SOC | Published : 2021

Abstract

Introduction. Mycoplasma genitalium is a sexually transmitted pathogen with increasing resistance to first- and second-line antimicrobials. The 'near-patient test' ResistancePlus MG FleXible (SpeeDx) detects M. genitalium plus four macrolide resistance mutations (MRMs), facilitating same-day patient follow up.Hypothesis/Gap Statement. This assay has not been assessed on freshly collected samples.Aim. Our goal was to evaluate the performance of the ResistancePlus MG FleXible test against the standard of care open platform test.Methods. ResistancePlus MG FleXible (analysed on the Cepheid GeneXpert platform) was evaluated on freshly collected samples and compared to the standard of care open pl..

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