Journal article

Assessment of Native Human Articular Cartilage: A Biomechanical Protocol

Wassif Kabir, Claudia Di Bella, Peter FM Choong, Cathal D O'Connell

Cartilage | SAGE PUBLICATIONS INC | Published : 2020


OBJECTIVES: Recapitulating the mechanical properties of articular cartilage (AC) is vital to facilitate the clinical translation of cartilage tissue engineering. Prior to evaluation of tissue-engineered constructs, it is fundamental to investigate the biomechanical properties of native AC under sudden, prolonged, and cyclic loads in a practical manner. However, previous studies have typically reported only the response of native AC to one or other of these loading regimes. We therefore developed a streamlined testing protocol to characterize the elastic and viscoelastic properties of human knee AC, generating values for several important parameters from the same sample. DESIGN: Human AC was ..

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Awarded by AOA Research Grant

Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the AOA Research Grant (Grant No. 528), Victorian Medical Research Acceleration Fund, and the Melbourne Medical School Mid Career Seeding Grant, The University of Melbourne.