Maternal exercise alters rat fetoplacental stress response: Minimal effects of maternal growth restriction and high-fat feeding
Yeukai TM Mangwiro, James SM Cuffe, Mark H Vickers, Clare M Reynolds, Dayana Mahizir, Kristina Anevska, Sogand Gravina, Tania Romano, Karen M Moritz, Jessica F Briffa, Mary E Wlodek
PLACENTA | W B SAUNDERS CO LTD | Published : 2021
INTRODUCTION: Fetal growth restriction complicates 10% of pregnancies and increases offspring (F1) risk of metabolic disorders, including obesity and gestational diabetes mellitus (GDM). This disease predisposition can be passed onto the next generation (F2). Importantly, the risk of pregnancy complications in obese women can be exacerbated by a stressful pregnancy. Exercise can reduce adiposity and improve health outcomes in obese women and those with GDM. This study investigated the impacts of maternal growth restriction, obesity, exercise, and stress on fetal and placental endocrine function. METHODS: Uteroplacental insufficiency (Restricted) or sham (Control) surgery was induced on embry..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
This research was supported by the National Health and Medical Research Council (NHMRC) of Australia (M.E.W.; 1045602) and a 2013 Diabetes Australia Research Trust Research Project (M.E.W). J.F.B. holds a Faculty of Medicine, Dentistry and Health Science Postdoctoral Fellowship at the University of Melbourne. Y.T.M.M. and K.A. held a La Trobe University Post Graduate Award and D.M. held a Malaysia Government Scholarship.