Folic acid dose, valproate, and fetal malformations
Frank JE Vajda, Terence J O'Brien, Janet E Graham, Alison A Hitchcock, Piero Perucca, Cecilie M Lander, Mervyn J Eadie
EPILEPSY & BEHAVIOR | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2021
OBJECTIVE: To determine whether there is a relationship between folic acid dose and the degree of protection against valproate-associated and other antiepileptic drug (AED)-associated fetal structural malformations in women with AED-treated epilepsy. METHODS: Statistical analysis of data from the Raoul Wallenberg Australian Register of Antiepileptic Drugs in Pregnancy involving 2104 folic acid-treated pregnancies in women with epilepsy. RESULTS: Multiple variable logistic regression failed to demonstrate any statistically significant effect of folic acid dosage in reducing overall fetal malformation rates in women taking folic acid either before and during pregnancy (P = 0.640) or during ear..View full abstract
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