Journal article

Latent Class Trajectory Modeling of Adult Body Mass Index and Risk of Obesity-Related Cancer: Findings from the Melbourne Collaborative Cohort Study

Yi Yang, Brigid M Lynch, Pierre-Antoine Dugue, Amalia Karahalios, Robert J MacInnis, Julie K Bassett, Alison McAleese, Craig Sinclair, Graham G Giles, Roger L Milne, Allison M Hodge, Dallas R English



BACKGROUND: Obesity increases the risk of 13 cancer types. Given the long process of carcinogenesis, it is important to determine the impact of patterns of body mass over time. METHODS: Using data from 30,377 participants in the Melbourne Collaborative Cohort Study, we identified body mass index (BMI) trajectories across adulthood and examined their association with the risk of obesity-related cancer. Participants completed interviews and questionnaires at baseline (1990-1994, age 40-69 years), follow-up 1 (1995-1998), and follow-up 2 (2003-2005). Body mass was recalled for age 18 to 21 years, measured at baseline, self-reported at follow-up 1, and measured at follow-up 2. Height was measure..

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Awarded by Victorian Cancer Agency

Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The authors thank all participants in the MCCS for their valuable contributions to the study. Y. Yang is supported by a Melbourne Research Scholarship from the University of Melbourne. B.M. Lynch is supported by a fellowship from the Victorian Cancer Agency (MCRF18005). Cohort recruitment of the MCCS was funded by Cancer Council Victoria ( and VicHealth ( MCCS was further supported by grants 209057, 251553, 396414, and 1074383 from the Australian National Health and Medical Research Council (NHMRC;, and ongoing follow-up and data management has been funded by Cancer Council Victoria since 1995.