An integrated metagenomics and metabolomics approach implicates the microbiota-gut-brain axis in the pathogenesis of Huntington's disease
Geraldine Kong, Susan Ellul, Vinod K Narayana, Komal Kanojia, Harvey Tran Thai Ha, Shanshan Li, Thibault Renoir, Le Cao Kim-Anh, Anthony J Hannan
NEUROBIOLOGY OF DISEASE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2021
BACKGROUND: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder with onset and severity of symptoms influenced by various environmental factors. Recent discoveries have highlighted the importance of the gastrointestinal microbiome in mediating the gut-brain-axis bidirectional communication via circulating factors. Using shotgun sequencing, we investigated the gut microbiome composition in the R6/1 transgenic mouse model of HD from 4 to 12 weeks of age (early adolescent through to adult stages). Targeted metabolomics was also performed on the blood plasma of these mice (n = 9 per group) at 12 weeks of age to investigate potential effects of gut dysbiosis on the plasm..View full abstract
Awarded by NHMRC
The shotgun sequencing was funded by a Computational Biology Research Initiative (CBRI) Grant to KALC and AJH, from the University of Melbourne. KALC is an NHMRC Career Development Fellow (GNT1159458). TR is an NHMRC-ARC Dementia Research Fellow. AJH is an NHMRC Principal Research Fellow. None of the funding bodies had any role in the design of the study or collection, analysis, and interpretation of data, or in writing the manuscript.