Controlled elevated temperatures during early-mid gestation cause placental insufficiency and implications for fetal growth in pregnant pigs
Weicheng Zhao, Fan Liu, Alan W Bell, Hieu H Le, Jeremy J Cottrell, Brian J Leury, Mark P Green, Frank R Dunshea
Scientific Reports | NATURE RESEARCH | Published : 2020
It is known that pig offspring born from pregnant pigs exposed to elevated ambient temperatures during gestation have altered phenotypes, possibly due to placental insufficiency and impaired fetal growth. Therefore, the objective of this study was to quantify the effect of maternal heat exposure during early-mid gestation, when pig placentae grow heavily, on placental and fetal development. Fifteen pregnant pigs were allocated to thermoneutral (TN; 20 °C; n = 7) or cyclic elevated temperature conditions (ET; 28 to 33 °C; n = 8) from d40 to d60 of gestation. Following euthanasia of the pigs on d60, placental and fetal morphometry and biochemistry were measured. Compared to TN fetuses, ET fetu..View full abstract
Awarded by Australian Pork Limited (APL)
This study was funded by Australian Pork Limited (APL; Project ID 2017-2216). Weicheng Zhao has been awarded an APL Postgraduate Research Scholarship and the Melbourne Research Scholarship.