Prevalence and clinical associations of tau in Lewy body dementias: A systematic review and meta-analysis
Kai Sin Chin, Nawaf Yassi, Leonid Churilov, Colin Louis Masters, Rosie Watson
Parkinsonism & Related Disorders | ELSEVIER SCI LTD | Published : 2020
INTRODUCTION: Alzheimer's disease neuropathologies (amyloid-β and tau) frequently co-exist to varying degrees in Lewy body dementias (LBD), which include dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). OBJECTIVES: To investigate the prevalence of tau in DLB and PDD, and its associations with clinical outcomes. METHODS: We searched the major electronic databases using the search term: ("dementia with Lewy bodies" OR "diffuse Lewy body disease" OR "Lewy body variant of Alzheimer's disease") AND ("tau protein" OR "tauopathy" OR "neurofibrillary tangle"), for relevant studies which evaluated tau in LBD. Forty-nine articles met the inclusion criteria for data extraction. W..View full abstract
Dr. Chin is supported by the Research Training Program Scholarship by the Australian Commonwealth Government and a PhD top-up scholarship from the Yulgilbar Foundation. Associate Prof. Yassi is supported by an NHMRC-ARC Dementia Research Development Fellowship and the Yulgilbar Foundation. Professors Churilov and Masters report no disclosures. Associate Prof. Watson is supported by the Yulgilbar Foundation.