Second- and third-trimester serum levels of growth-differentiation factor-15 in prediction of pre-eclampsia.
D Wertaschnigg, DL Rolnik, G Nie, SSY Teoh, A Syngelaki, F da Silva Costa, KH Nicolaides
Ultrasound in Obstetrics and Gynecology | Published : 2020
OBJECTIVE: Pre-eclampsia (PE) is a significant contributor to adverse maternal and perinatal outcome; however, accurate prediction and early diagnosis of this condition remain a challenge. The aim of this study was to compare serum levels of growth-differentiation factor-15 (GDF-15) at three different gestational ages between asymptomatic women who subsequently developed preterm or term PE and healthy controls. METHODS: This was a case-control study drawn from a prospective observational study on adverse pregnancy outcomes in women attending for their routine second- and third-trimester hospital visits. Serum GDF-15 was determined in 300 samples using a commercial GDF-15 enzyme-linked immuno..View full abstract