Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers
John B Furness, Ruslan Pustovit, Andrew J Syder, Mitchell T Ringuet, Eun Ji Yoo, Andrea Fanjul, Jill Wykosky, Linda J Fothergill, Emily A Whitfield, Sebastian GB Furness
Neurogastroenterology & Motility | WILEY | Published : 2020
BACKGROUND: Dopamine receptor 2 (DRD2) and ghrelin receptor (GHSR1a) agonists both stimulate defecation by actions at the lumbosacral defecation center. Dopamine is in nerve terminals surrounding autonomic neurons of the defecation center, whereas ghrelin is not present in the spinal cord. Dopamine at D2 receptors generally inhibits neurons, but at the defecation center, its effect is excitatory. METHODS: In vivo recording of defecation and colorectal propulsion was used to investigate interaction between DRD2 and GHSR1a. Localization studies were used to determine sites of receptor expression in rat and human spinal cord. KEY RESULTS: Dopamine, and the DRD2 agonist, quinpirole, directly app..View full abstract
Awarded by NHMRC
Awarded by Australian Research Council
This work was supported by NHMRC project grant APP1145686 to JBF and by the Takeda Pharmaceutical Company Limited. MTR is supported by a PhD bursary from the University of Melbourne. SGBF is supported by a Future Fellowship (FT180100543) of the Australian Research Council.