Population genomics and antimicrobial resistance in Corynebacterium diphtheriae
Melanie Hennart, Leonardo G Panunzi, Carla Rodrigues, Quentin Gaday, Sarah L Baines, Marina Barros-Pinkelnig, Annick Carmi-Leroy, Melody Dazas, Anne Marie Wehenkel, Xavier Didelot, Julie Toubiana, Edgar Badell, Sylvain Brisse
Genome Medicine | BMC | Published : 2020
BACKGROUND: Corynebacterium diphtheriae, the agent of diphtheria, is a genetically diverse bacterial species. Although antimicrobial resistance has emerged against several drugs including first-line penicillin, the genomic determinants and population dynamics of resistance are largely unknown for this neglected human pathogen. METHODS: Here, we analyzed the associations of antimicrobial susceptibility phenotypes, diphtheria toxin production, and genomic features in C. diphtheriae. We used 247 strains collected over several decades in multiple world regions, including the 163 clinical isolates collected prospectively from 2008 to 2017 in France mainland and overseas territories. RESULTS: Phyl..View full abstract
Awarded by European Union
Awarded by MTCI PhD school
Awarded by French government's Investissement d'Avenir program Laboratoire d'Excellence "Integrative Biology of Emerging Infectious Diseases"
MH was supported financially by a PhD grant from the European Joint Programme One Health, which has received funding from the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No. 773830. LGP was supported financially by a grant from the Institut Francais de Bioinformatique, the national infrastructure for services in bioinformatics created in the frame of the French Government's Investissement d'Avenir program. QG was funded by MTCI PhD school (ED 563). CR was supported by a Pasteur-Roux fellowship from Institut Pasteur. SLB received support from a Victorian Fellowship, provided by VESKI and funded by the State Government of Victoria, Australia.The National Reference Center for Corynebacteria of the Diphtheriae complex receives support from Institut Pasteur and Public Health France (Sante Publique France, Saint Maurice, France). This work was supported financially by the French government's Investissement d'Avenir program Laboratoire d'Excellence "Integrative Biology of Emerging Infectious Diseases" (ANR-10LABX-62-IBEID). AW and QG receive support from Institut Pasteur and the CNRS (France).