Journal article

Plasmin Generation Potential and Recanalization in Acute Ischaemic Stroke; an Observational Cohort Study of Stroke Biobank Samples

Thomas Lillicrap, Charithani B Keragala, Dominik F Draxler, Jilly Chan, Heidi Ho, Stevi Harman, Be'eri Niego, Elizabeth Holliday, Christopher R Levi, Carlos Garcia-Esperon, Neil Spratt, Prajwal Gyawali, Andrew Bivard, Mark W Parsons, Joan Montaner, Alejandro Bustamante, Israel Fernandez Cadenas, Geoffrey Cloud, Jane M Maguire, Lisa Lincz Show all

Frontiers in Neurology | FRONTIERS MEDIA SA | Published : 2020

Abstract

Rationale: More than half of patients who receive thrombolysis for acute ischaemic stroke fail to recanalize. Elucidating biological factors which predict recanalization could identify therapeutic targets for increasing thrombolysis success. Hypothesis: We hypothesize that individual patient plasmin potential, as measured by in vitro response to recombinant tissue-type plasminogen activator (rt-PA), is a biomarker of rt-PA response, and that patients with greater plasmin response are more likely to recanalize early. Methods: This study will use historical samples from the Barcelona Stroke Thrombolysis Biobank, comprised of 350 pre-thrombolysis plasma samples from ischaemic stroke patients wh..

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Grants

Awarded by Australian National Health and Medical Research Council


Funding Acknowledgements

This study was funded by competitive grants from the Australian National Health and Medical Research Council (Reference APP1085550).