Plasmin Generation Potential and Recanalization in Acute Ischaemic Stroke; an Observational Cohort Study of Stroke Biobank Samples
Thomas Lillicrap, Charithani B Keragala, Dominik F Draxler, Jilly Chan, Heidi Ho, Stevi Harman, Be'eri Niego, Elizabeth Holliday, Christopher R Levi, Carlos Garcia-Esperon, Neil Spratt, Prajwal Gyawali, Andrew Bivard, Mark W Parsons, Joan Montaner, Alejandro Bustamante, Israel Fernandez Cadenas, Geoffrey Cloud, Jane M Maguire, Lisa Lincz Show all
Frontiers in Neurology | FRONTIERS MEDIA SA | Published : 2020
Rationale: More than half of patients who receive thrombolysis for acute ischaemic stroke fail to recanalize. Elucidating biological factors which predict recanalization could identify therapeutic targets for increasing thrombolysis success. Hypothesis: We hypothesize that individual patient plasmin potential, as measured by in vitro response to recombinant tissue-type plasminogen activator (rt-PA), is a biomarker of rt-PA response, and that patients with greater plasmin response are more likely to recanalize early. Methods: This study will use historical samples from the Barcelona Stroke Thrombolysis Biobank, comprised of 350 pre-thrombolysis plasma samples from ischaemic stroke patients wh..View full abstract
Awarded by Australian National Health and Medical Research Council
This study was funded by competitive grants from the Australian National Health and Medical Research Council (Reference APP1085550).