Journal article

Metastatic Squamous Cell Carcinoma to the Cervical Lymph Nodes From an Unknown Primary Cancer: Management in the HPV Era

Francisco J Civantos, Jan B Vermorken, Jatin P Shah, Alessandra Rinaldo, Carlos Suarez, Luiz P Kowalski, Juan P Rodrigo, Kerry Olsen, Primoz Strojan, Antti A Makitie, Robert P Takes, Remco de Bree, June Corry, Vinidh Paleri, Ashok R Shaha, Dana M Hartl, William Mendenhall, Cesare Piazza, Michael Hinni, K Thomas Robbins Show all

Frontiers in Oncology | FRONTIERS MEDIA SA | Published : 2020


Background: Patients with metastases in the lymph nodes of the neck and no obvious primary tumor, neck cancer with unknown primary (NCUP), represent a management challenge. A majority of patients have metastatic squamous cell carcinoma (SCC), although other histologies do occur. Methods: We comprehensively reviewed the literature, compared available guidelines, and conferred with an international team of experts. Results: Positron emission tomography-computed tomography (PET-CT) and fine needle aspiration (FNA) under ultrasound guidance increase accuracy of diagnosis. Immunohistochemistry (IHC), determination of human papilloma virus (HPV) status, by p16 staining or by in situ hybridization ..

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University of Melbourne Researchers