Prospectively assessed neurodevelopmental outcomes in studies of anaesthetic neurotoxicity in children: a systematic review and meta-analysis
Caleb Ing, William M Jackson, Michael J Zaccariello, Terry E Goldberg, Mary-Ellen McCann, Anneke Grobler, Andrew Davidson, Lena Sun, Guohua Li, David O Warner
BRITISH JOURNAL OF ANAESTHESIA | ELSEVIER SCI LTD | Published : 2021
BACKGROUND: Whether exposure to a single general anaesthetic (GA) in early childhood causes long-term neurodevelopmental problems remains unclear. METHODS: PubMed/MEDLINE, Embase, CINAHL, Web of Science, and the Cochrane Library were searched from inception to October 2019. Studies evaluating neurodevelopmental outcomes and prospectively enrolling children exposed to a single GA procedure compared with unexposed children were identified. Outcomes common to at least three studies were evaluated using random-effects meta-analyses. RESULTS: Full-scale intelligence quotient (FSIQ); the parentally reported Child Behavior Checklist (CBCL) total, externalising, and internalising problems scores; an..View full abstract
Awarded by Agency for Healthcare Research and Quality (AHRQ)
Agency for Healthcare Research and Quality (AHRQ) (R01 HS026493) to CI.