Journal article

Prospectively assessed neurodevelopmental outcomes in studies of anaesthetic neurotoxicity in children: a systematic review and meta-analysis

Caleb Ing, William M Jackson, Michael J Zaccariello, Terry E Goldberg, Mary-Ellen McCann, Anneke Grobler, Andrew Davidson, Lena Sun, Guohua Li, David O Warner

BRITISH JOURNAL OF ANAESTHESIA | ELSEVIER SCI LTD | Published : 2021

Abstract

BACKGROUND: Whether exposure to a single general anaesthetic (GA) in early childhood causes long-term neurodevelopmental problems remains unclear. METHODS: PubMed/MEDLINE, Embase, CINAHL, Web of Science, and the Cochrane Library were searched from inception to October 2019. Studies evaluating neurodevelopmental outcomes and prospectively enrolling children exposed to a single GA procedure compared with unexposed children were identified. Outcomes common to at least three studies were evaluated using random-effects meta-analyses. RESULTS: Full-scale intelligence quotient (FSIQ); the parentally reported Child Behavior Checklist (CBCL) total, externalising, and internalising problems scores; an..

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