Molecular and spatial mechanisms governing STING signalling
Katherine R Balka, Dominic De Nardo
The FEBS Journal | WILEY | Published : 2020
Detection of microbial nucleic acids via innate immune receptors is critical for establishing host defence against pathogens. The DNA-sensing cGAS-STING pathway has gained increasing attention in the last decade as a key pathway for combating viral and bacterial infections. cGAS-STING activation primarily promotes the secretion of antiviral type I IFNs via the key transcription factor, IRF3. In addition, cGAS-STING signalling also elicits pro-inflammatory cytokines through NF-κB activity. Activation of IRF3 and NF-κB is mediated by the chief signalling receptor protein STING. Interestingly, STING undergoes significant trafficking events across multiple subcellular locations, which regulates ..View full abstract
We would like to thank Professor Benjamin Kile and members of the Kile laboratory (Monash University) for their support and interesting discussions related to the cGAS-STING pathway. We also acknowledge work from authors in the field whom we were unable to include in this review. KRB is supported by a Monash Silver Jubilee Postgraduate Research scholarship (MSJS) and a Monash Graduate Excellence scholarship; DDN is supported, in part, by a Monash University FMNHS Senior Postdoctoral Fellowship.