Journal article

APC regulation of ESRP1 and p120-catenin isoforms in colorectal cancer cells

Maree C Faux, Lauren E King, Serena R Kane, Christopher Love, Oliver M Sieber, Antony W Burgess

MOLECULAR BIOLOGY OF THE CELL | AMER SOC CELL BIOLOGY | Published : 2021

Abstract

The adenomatous polyposis coli (APC) tumor suppressor protein is associated with the regulation of Wnt signaling; however, APC also controls other cellular processes including the regulation of cell adhesion and migration. The expression of full-length APC in SW480 colorectal cancer cells (SW480+APC) not only reduces Wnt signaling, but increases membrane E-cadherin and restores cell-cell adhesion. This report describes the effects of full-length, wild-type APC (fl-APC) on cell-cell adhesion genes and p120-catenin isoform switching in SW480 colon cancer cells: fl-APC increased the expression of genes implicated in cell-cell adhesion, whereas the expression of negative regulators of E-cadherin..

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Grants

Awarded by National Health and Medical Research Council (NH&MRC) Program Grant


Funding Acknowledgements

This work was supported by National Health and Medical Research Council (NH&MRC) Program Grant #487922. The funding body had no role in the design of the study, collection, analysis, or interpretation of data or in writing the manuscript. This work was also supported by the Walter and Eliza Hall Institute. We thank the members of the Burgess laboratory for critical evaluation of the data.