Journal article

Epilepsy risk in offspring of affected parents; a cohort study of the "maternal effect" in epilepsy

Julie W Dreier, Colin A Ellis, Samuel F Berkovic, Chris Cotsapas, Ruth Ottman, Jakob Christensen

Annals of Clinical and Translational Neurology | WILEY | Published : 2020


OBJECTIVE: To assess whether the risk of epilepsy is higher in offspring of mothers with epilepsy than in offspring of fathers with epilepsy. METHODS: In a prospective population-based register study, we considered all singletons born in Denmark between 1981 and 2016 (N = 1,754,742). From the Danish National Patient Register since 1977, we identified epilepsy diagnoses in all study participants and their family members. Cox regression models were used to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CI), adjusted for relevant confounders. RESULTS: We included 1,754,742 individuals contributing > 30 million person-years of follow-up. The incidence rate of epilepsy i..

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University of Melbourne Researchers


Awarded by National Institute of Neurological Disorders and Stroke

Awarded by Novo Nordisk Foundation

Awarded by NIH

Funding Acknowledgements

This work was supported by the National Institute of Neurological Disorders and Stroke (1R01NS106104-01A1), the Novo Nordisk Foundation (NNF16OC0019126), Central Denmark Region, and the Danish Epilepsy Association. R.O. was supported by NIH grants R01 NS104076 and P50 HG007257.