Is Viral Vector Gene Delivery More Effective Using Biomaterials?
Yi Wang, Kiara F Bruggeman, Stephanie Franks, Vini Gautam, Stuart I Hodgetts, Alan R Harvey, Richard J Williams, David R Nisbet
ADVANCED HEALTHCARE MATERIALS | WILEY | Published : 2020
Gene delivery has been extensively investigated for introducing foreign genetic material into cells to promote expression of therapeutic proteins or to silence relevant genes. This approach can regulate genetic or epigenetic disorders, offering an attractive alternative to pharmacological therapy or invasive protein delivery options. However, the exciting potential of viral gene therapy has yet to be fully realized, with a number of clinical trials failing to deliver optimal therapeutic outcomes. Reasons for this include difficulty in achieving localized delivery, and subsequently lower efficacy at the target site, as well as poor or inconsistent transduction efficiency. Thus, ongoing effort..View full abstract