Journal article

Mode of birth and risk of infection-related hospitalisation in childhood: A population cohort study of 7.17 million births from 4 high-income countries

Jessica E Miller, Raphael Goldacre, Hannah C Moore, Justin Zeltzer, Marian Knight, Carole Morris, Sian Nowell, Rachael Wood, Kim W Carter, Parveen Fathima, Nicholas de Klerk, Tobias Strunk, Jiong Li, Natasha Nassar, Lars H Pedersen, David P Burgner

PLoS Medicine | PUBLIC LIBRARY SCIENCE | Published : 2020


BACKGROUND: The proportion of births via cesarean section (CS) varies worldwide and in many countries exceeds WHO-recommended rates. Long-term health outcomes for children born by CS are poorly understood, but limited data suggest that CS is associated with increased infection-related hospitalisation. We investigated the relationship between mode of birth and childhood infection-related hospitalisation in high-income countries with varying CS rates. METHODS AND FINDINGS: We conducted a multicountry population-based cohort study of all recorded singleton live births from January 1, 1996 to December 31, 2015 using record-linked birth and hospitalisation data from Denmark, Scotland, England, an..

View full abstract


Awarded by National Health and Medical Research Council project

Awarded by Novo Nordisk Foundation

Awarded by Danish Council for Independent Research

Funding Acknowledgements

NdK, KWC, and DPB received funding from National Health and Medical Research Council project grants (GTN1065494: NdK, KWC, DPB), (GTN1045668: HCM, NdK), Fellowship (1034254: HCM), and Senior Research Fellowship (GTN1064629: DPB); JEM received funding from the DHB Foundation; LHP received funding from Health Research Fund of Central Denmark Region; JL received funding from the Novo Nordisk Foundation (NNF18OC0052029), and the Danish Council for Independent Research (DFF-6110-00019); NN received funding from Financial Markets Foundation for Children; TS received funding from Raine Foundation Clinician Research Fellowship; RG and MK received funding from Public Health England, the Li Ka Shing Foundation, the Robertson Foundation, the Medical Research Council, British Heart Foundation, and the NIHR Oxford Biomedical Research Centre funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.