Journal article

Mode of birth and risk of infection-related hospitalisation in childhood: A population cohort study of 7.17 million births from 4 high-income countries

Jessica E Miller, Raphael Goldacre, Hannah C Moore, Justin Zeltzer, Marian Knight, Carole Morris, Sian Nowell, Rachael Wood, Kim W Carter, Parveen Fathima, Nicholas de Klerk, Tobias Strunk, Jiong Li, Natasha Nassar, Lars H Pedersen, David P Burgner

PLoS Medicine | PUBLIC LIBRARY SCIENCE | Published : 2020

Abstract

BACKGROUND: The proportion of births via cesarean section (CS) varies worldwide and in many countries exceeds WHO-recommended rates. Long-term health outcomes for children born by CS are poorly understood, but limited data suggest that CS is associated with increased infection-related hospitalisation. We investigated the relationship between mode of birth and childhood infection-related hospitalisation in high-income countries with varying CS rates. METHODS AND FINDINGS: We conducted a multicountry population-based cohort study of all recorded singleton live births from January 1, 1996 to December 31, 2015 using record-linked birth and hospitalisation data from Denmark, Scotland, England, an..

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Grants

Awarded by National Health and Medical Research Council project


Awarded by Novo Nordisk Foundation


Awarded by Danish Council for Independent Research


Funding Acknowledgements

NdK, KWC, and DPB received funding from National Health and Medical Research Council project grants www.nhmrc.gov.au (GTN1065494: NdK, KWC, DPB), (GTN1045668: HCM, NdK), Fellowship (1034254: HCM), and Senior Research Fellowship (GTN1064629: DPB); JEM received funding from the DHB Foundation; LHP received funding from Health Research Fund of Central Denmark Region; JL received funding from the Novo Nordisk Foundation www.novonordisk.com (NNF18OC0052029), and the Danish Council for Independent Research https://dff.dk/en (DFF-6110-00019); NN received funding from Financial Markets Foundation for Children www.foundationforchildren.com.au; TS received funding from Raine Foundation Clinician Research Fellowship http://rainefoundation.org.au; RG and MK received funding from Public Health England www.gov.uk/government/organisations/publichealth-england, the Li Ka Shing Foundation www.lksf.org, the Robertson Foundation www.robertsonfoundation.org, the Medical Research Council https://mrc.ukri.org, British Heart Foundation www.bhf.org.uk, and the NIHR Oxford Biomedical Research Centre https://oxfordbrc.nihr.ac.uk.The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.